Propylphosphonic Anhydride (T3P®) as Coupling Reagent for Solid‐Phase Peptide Synthesis

Propylphosphonic anhydride (T3P) mediated synthesis of novel 2-aryl quiolines and evaluation of their anticancer activity

A novel reagent, dialkylphosphite, for peptide synthesis.

The same dialkylphosphite reagent can be used for both N protection and C activation of amino acids. Two N-diisopropyloxyphosphinyl (Dipp) tripeptide esters were prepared, and nine N-Dipp-dipeptide acids were synthesized through the activated amide intermediate. The positive ion FAB-MS of N-Dipp-tripeptide showed novel cleavage patterns in that only the N-phosphoryl fragment ions gave intense p...

Lead Tetraacetatelchromic Anhydride Combination as a Novel Reagent for the Selective Oxidation of Methylene Dioxide Function

Pb(OAc) /Cr0 combination was found to be able to oxidize methylene dioxide function in the presence of diphenylmethane moiety

Search for optimal coupling reagent in multiple peptide synthesizer.

Ten different coupling reagents and their combinations were tested in parallel in the synthesis of four model peptide sequences. Significant differences were found between uronium and phosphonium salt-based reagents and carbodiimide. Diisopropylcarbodiimide was identified as an optimal reagent based on the purity of the product, stability of the reagent, and convenience of handling on plate-bas...

Synthesis of Spermidine using Solidphase Synthetic Strategy

Spermidine is a naturally occurring polyamine which regulate growth processes in living beings. Using solid phase synthetic strategy spermidine was synthesised. The only purification process involved throughout the synthesis is filtration and washing with suitable solvents. Spermidine was first synthesised over polystyrene support and then cleaved from matrix photolytically. The yield and purit...